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Principal Investigator

Paul Dayton, Ph.D

Professor

Paul Dayton received his B.S. in Physics from Villanova University in 1995, his M.E. in Electrical Engineering from the University of Virginia in 1998, and his Ph.D. in Biomedical Engineering in 2001, also from the University of Virginia.  He pursued post-doctoral research and was later research faculty at the University of California at Davis.  Much of Dr. Dayton’s training was under the mentorship of Dr. Katherine Ferrara, where his initial studies involved high speed optical and acoustical analysis of individual contrast agent microbubbles.  In 2007, Dr. Dayton moved to the Joint Department of Biomedical Engineering at UNC Chapel Hill and NC State University, Raleigh, where he is now Associate Professor and Associate Department Chair.   Dr. Dayton is currently Associate Director for Education for the Biomedical Imaging Research Center, and his research interests involve ultrasound contrast imaging, ultrasound-mediated therapies, and medical devices.  Dr. Dayton is a member of the technical program committee for IEEE UFFC, and a member of the editorial boards for the journals IEEE Ultrasonics, Ferroelectrics, and Frequency Control as well as Molecular Imaging, and Bubble Science, Engineering, and Technology.


 

Laboratory Staff

James Tsuruta, Ph.D

Research Assistant Professor

Dr. Tsuruta is a faculty member in the department of pediatrics and cell and developmental biology.  His work involves the interactions of ultrasound with biological tissues.  Dr. Tsuruta also contributes his knowledge of biochemistry to histology and molecular targeting applications.

 

 

Kennita Johnson, Ph.D

Research Assistant Professor

Kennita received her bachelor’s degree in Physics from the University of Maryland Baltimore County (UMBC).  She attended University of Florida where she received a master’s degree in medical physics and a doctoral degree in biomedical engineering.  She completed a postdoctoral fellowship at the National Institute of Environmental Health Sciences in small animal imaging before coming to the Dayton Lab.  Besides her duties as lab manager, she conducts destruction-reperfusion ultrasound imaging on kidney disease models.

 

Virginie Papadopoulou, Ph.D

Research Assistant Professor – Divers Alert Network Scholar

Virginie received her PhD in Bioengineering from Imperial College London, UK, in 2016, after completing a Master’s degree in Physics in the same university in 2011. Her PhD thesis focused on bubble formation, growth and circulation dynamics in vivo from hyperbaric decompression, relevant to scuba divers and astronauts to prevent decompression sickness. Concurrently as an EU Marie Curie fellow (2012-2014) and COST MP1106 member (2011-2014), she spent time in Belgium working on hyperbaric physiology and in Greece on hyperbaric bubble growth instrumentation. From January 2015 to March 2016 she worked as a postdoc under the supervision of Dr Tang at Imperial College London on 3D ultrasound contrast enhanced flow reconstruction from lab prototype to first human application. She joined the Dayton Lab as a postdoc in May 2016, where her main research focuses on tumor oxygen microbubble therapy combinations and nanodroplet acoustic vaporization.

 

Brian Velasco, BA

Senior Research Technician/Laboratory Manager

 

 

 

 

 

 

Marjan Mehrab Mohseni, MS

Research Technician

Marjan Mehrab-Mohseni received a BS in Applied Chemistry from Tehran University, Iran, an MSc in Molecular Cell Biology from Uppsala University, Sweden in 2008. Marjan started her research working on the molecular pathogenesis of liver disease. During her master thesis at Karolinska Institute, she worked on cancer epigenetics and showed that human cytomegalovirus infection alters global DNA methylation capacity. Following immigration to United States, Marjan worked on the molecular pathogenesis of HCV at Carolinas Medical Center where she showed that Legaoln-Sil can down-regulate HCV in vitro through altering expression of tight junction components. Marjan research has so far led to more than 10 publications and 200 citations in prestigious journals. Marjan currently doing her research at UNC under supervision of Dr. Paul Dayton from BME and Dr. Samantha Pattendon from UNC School of pharmacy. In here recent work, Marjan has developed a novel cavitation-enhancement nanodroplet reagent which can decrease the time and acoustic energy required for gDNA fragmentation. gDNA is one the most sensitive, time- consuming steps of epigenetic assays like, CHIP, Fair and next-generation sequencing. Marjan has also showed that cavitation enhancement increases the efficiency and consistency of chromatin fragmentation from fixed cells for downstream quantitative applications.

 

Post-Doctoral Fellows

Jinwook Kim, Ph.D

Jinwook received his B.S. and M. S. degrees in Mechanical Engineering from Kyungpook National University in 2010 and 2012, respectively, for his work in piezocomposite transducers for underwater ultrasound. He received a Ph.D. in Mechanical Engineering from North Carolina State University for his work in miniaturized ultrasound transducers for the acoustic excitation of microbubbles and microgels. He joined Dayton lab in September 2017 as a post-doctoral researcher. His current works include intravascular acoustic angiography, intravascular sonothrombolysis, and laser-generated ultrasound transducers for nanodroplet/microbubble-mediated ultrasound therapies. In collaboration with the Jiang lab (NCSU), he works on development of novel imaging and therapeutic transducers. His research interests include minimally-invasive imaging and therapeutic transducers, ultrasound-triggered drug delivery and nanodroplet-aided ultrasound therapies. 

Amber Shea Moody, Ph.D

Dr. Moody received her PhD in 2018 from the University of Tennessee in Physical Chemistry. Her dissertation work focused on developing a detection method for biomarkers of neurodegenerative diseases using Raman spectroscopy. She then earned a postdoctoral fellowship at the National Center for Toxicological Research (NCTR), the primary research facility for the US FDA. At NCTR she used immunohistochemistry to study the toxicity of general anesthesia on the developing brain. She is currently a member of the T32 Cancer Nanotechnology program working under Dr. Paul Dayton and Dr. William Zamboni. Her research combines pharmacokinetic and advanced ultrasound imaging methods to modulate the tumor microenvironment in order to increase the tumor delivery and efficacy of nanoparticles chemotherapeutics.


Graduate Students

Isabel (Izzie) Newsome

Izzie received her BS degree in Physics from Clarkson University in Potsdam, NY in May 2016. She performed undergraduate research in the field of biophysics, focused on investigating the mechanical properties of the endothelial glycocalyx through a biomimetic microfluidic system. Currently, she is a PhD candidate in the Joint Department of Biomedical Engineering at UNC and NCSU. In the Dayton Lab, Izzie’s research focuses on acoustic angiography, a non-invasive microvascular ultrasound imaging technique, and she aims to adapt preclinical acoustic angiography for clinical use in the evaluation of angiogenesis as a biomarker of malignant cancer. Izzie is a trainee in the Integrative Vascular Biology program and a recipient of a Ruth L. Kirschstein Predoctoral Individual National Research Service Award from the National Cancer Institute.

Rachel White

Rachel graduated with her Bachelor’s degree in Biomedical Engineering from the University of Delaware in 2016. She is now working towards her PhD in Biomedical Engineering at UNC Chapel Hill. In the Dayton lab, she focuses on advancing clinical applications of contrast-enhanced ultrasound. Her research projects include using targeted microbubbles to track patient response to therapy and exploring the value of ultrasound contrast agents for kidney imaging and diagnosis.

 

 

 

Thomas Kierski

Thomas received the B.S. in Biomedical Engineering from the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill and North Carolina State University in 2017. In the Dayton lab, he is investigating new technologies related to microvascular imaging. These include ultrafast superharmonic imaging for localization microscopy, super-resolution molecular imaging, as well as deep learning for image processing and interpretation.

 

 

 

Ryan DeRuiter

Ryan was born and raised in Cary, North Carolina. He left the state for his undergraduate education at Mercer University. There he earned a Bachelor of Science in Engineering (BSE) degree, specializing in biomedical engineering and minoring in mathematics. Ryan joined the Dayton and Pinton Labs in the Fall of 2017. His current research focus is super-resolution ultrasound imaging via ultrafast ultrasound localization microscopy (uULM).

 

 

 

David Le

David graduated from George Mason University with a Bachelor’s in Bioengineering where his research focused on using ultrasound elasticity imaging to study chronic illnesses. He joined the Dayton Lab in Fall 2017 to pursue a Ph.D. in Biomedical Engineering at UNC-CH. His research interests are in developing nonlinear and ultra-fast ultrasound imaging techniques. Current projects include (1) studying microbubble coalescence due to imaging and therapeutic ultrasound application (2) using ultrafast contrast-enhanced ultrasound to study blood flow dynamics for diabetic kidney disease and (3) developing ultrasound techniques and tools to study decompression sickness in divers.

 

 

Phillip Durham

 

Jordan Baer Joiner

Jordan is a Pharmaceutical Sciences Ph.D. student in the Division of Pharmacoengineering and Molecular Pharmaceutics. She is originally from Fort Worth, Texas and received her Bachelor’s degree in Chemical and Biological Engineering from the University of Alabama. After undergrad, she spent 3 years working as a Drug Formulations Process Engineer at Evonik Corporation where she worked on the scale up of microparticle formulations. Jordan joined the Dayton Lab in January 2019, and is combining therapeutic ultrasound with immunotherapy to treat pancreatic cancer. She also works in the lab of Dr. Rahima Benhabbour to formulate injectable in-situ forming implants that sustain drug release and can be non-invasively imaged with ultrasound.

Jake McCall

Jake received his B.S. in Electrical Engineering from the University of Mississippi in 2019. He is now a student at NC State University pursuing a PhD in Electrical and Computer Engineering. Jake joined the Dayton Lab in Fall 2019, where he is currently working on the implementation of ultrasound imaging methods in newer ultrasound systems.

Kathlyne Bautista

Kathlyne graduated with a B.S. in Biomedical Engineering from the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill and North Carolina State University in 2020. In Fall 2020, she is joining the Dayton Lab as a first-year PhD student.

 

 

 

Undergraduate Students

Erica McCune

 

 

Martin Joseph Smolka

 

Kamellia Karimpour

 

 

 

 

 

Hannah Lynn McCurry